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Research Integrity & Status Transparency

All research outputs are labelled by peer-review status: Peer-Reviewed · Preprint · Active · Enrolling · Preliminary. No premature clinical claims are made. Findings are interpreted conservatively and within the scope of study design. Pre-registered statistical analysis plans (SAPs) are locked prior to data collection. Independent statisticians verify all primary analyses. All datasets are openly archived. MMSx Authority operates 8 active research streams spanning core biomechanics, AI integration, and nutritional science — with 17 registered studies and a combined participant pool exceeding 28,955.

§ 01

Active Research Streams

#streams
Stream ID Domain Keywords PI / Lead Status
RS-001
Spine & Load-Tolerance Science
Torque-demand vs. extensor-capacity modelling; spinal segment mechanics under load
IAP · L5/S1 Shear · Torque · EMG Trunk · Panjabi
Dr. Neeraj Mehta
Active
RS-002
Gait, Locomotion & Load Distribution
GRF dynamics, COM regulation, plantar load, temporal-spatial gait parameters
GRF · Plantar Load · IMU · Symmetry · COM
Dr. Neeraj Mehta
Active
RS-003
Strength & Performance Biomechanics
Force-vector optimisation, SSC mechanics, RFD, kinetic chain load-sharing strategies
Force Vectors · RFD · Bar Path · SSC · Fatigue
Dr. Neeraj Mehta
Active
RS-004
Neuromechanical Control
Anti-rotation, anti-lateral flexion, proprioceptive regulation, dynamic mechanical load
Proprioception · Co-contraction · HRV · EMG
Dr. Neeraj Mehta
Active
RS-005
Clinical Movement Dysfunction & Rehabilitation
MMSx-SCAN™ multi-site registry; staged correction pathways; load-tolerance restoration
MMSx-SCAN · MOVE · BPIT · Kinetic Chain · Rehab
Dr. Neeraj Mehta
Enrolling
RS-006
Prosthetics, Orthotics & Footwear Biomechanics
Human-device interface pressures, compensatory gait, footwear-mediated load redistribution
Pressure Map · Device Interface · Footwear · AFO
Dr. Neeraj Mehta
Developing
RS-007
Artificial Intelligence & Biomechanics
AI-driven movement pattern recognition, pose estimation, automated kinematic analysis, predictive load modelling
Pose Estimation · ML · Computer Vision · LSTM · Digital Twin
Dr. Neeraj Mehta
Active
RS-008
Nutrition & Biomechanics
Nutritional modulation of musculoskeletal load tolerance, connective tissue integrity, and neuromuscular recovery under mechanical stress
Collagen · Protein Synthesis · HRV · Inflammation · Recovery
Dr. Neeraj Mehta
Developing
RS-005 · PRIMARY CLINICAL STREAM
Clinical Movement Dysfunction & Rehabilitation Translation

The central clinical stream of the MMSx Authority research program. Investigates movement dysfunction patterns, staged corrective sequencing, and return-to-activity frameworks using a structured multi-site registry approach. The MMSx-SCAN™ assessment tool provides the inter-rater reliability and normative reference infrastructure for this stream.

Primary Instruments
MMSx-SCAN™ (n=870, ICC 0.91 inter-rater reliability) · MOVE Protocol™ (NCT07220200) · BPIT 5-Line Framework (NCT07296640, NCT07256717)
Statistical Methods
ICC(2,1) Shrout & Fleiss · Paired t-tests (α=0.05) · Cohen's d effect size · SEM · MDC95 · Intra-class analysis · Mixed-effects ANOVA
Active · Multi-Site ClinicalTrials.gov n=28,955+ combined GCP ICH E6(R3) Open Dataset
RS-001 · SPINE SCIENCE
Spine & Load-Tolerance Science

Spinal biomechanics treated as a load-pathway decision problem. Quantifies extensor torque demand vs. muscle capacity under progressive loading — with application to manual handling, rehabilitation, and performance programming.

Key Variables
L5/S1 compression & shear · Intra-abdominal pressure (IAP) · Erector spinae EMG · Trunk moment arms · Spinal neutral zone
Active Torque Modelling EMG IAP
RS-003 · PERFORMANCE
Strength & Performance Biomechanics

Mechanical efficiency of high-load and high-velocity movement. Applies force-vector analysis to resistance training, plyometrics, and sport-specific skill — with emphasis on load distribution across kinetic chain segments.

Key Variables
Rate of force development (RFD) · SSC utilisation ratio · Vector angle vs. moment arm · Bar path deviation · Segmental power transfer
Active Force Plates 3D Motion Capture IMU
RS-004 · NEUROMECHANICS
Neuromechanical Control

Regulation of joint stability and load tolerance through proprioceptive and neuromuscular mechanisms. Investigates HRV as a systemic marker of mechanical recovery and adaptation under progressive training load.

Key Variables
HRV (rMSSD · SDNN) · Co-contraction indices · sEMG activation timing · Knee valgus angle · Balance error scoring
Active HRV sEMG Valgus
RS-007 · AI & BIOMECHANICS
Artificial Intelligence & Biomechanics

Integration of machine learning, computer vision, and pose-estimation technologies with clinical biomechanics frameworks. Develops AI-assisted movement screening tools, predictive load models, and automated kinematic assessment pipelines for use across clinical and field-based settings — including the TrainersEye platform.

Methods & Technologies
Markerless pose estimation (MediaPipe, OpenPose) · LSTM temporal sequence modelling · CNN movement classification · Digital twin biomechanics · Automated joint angle extraction
Applied Platforms
TrainersEye AI · MoPro Bot · Motion Map Analysis · MMO Assessment — all operating within the MMSx Authority technology ecosystem
Active Computer Vision Pose Estimation LSTM Digital Twin
RS-008 · NUTRITION & BIOMECHANICS
Nutrition & Biomechanics

Investigates the role of nutritional status in modulating musculoskeletal load tolerance, connective tissue integrity, and neuromuscular recovery under progressive mechanical stress. Bridges nutritional biochemistry with applied biomechanics to understand how macro- and micronutrient availability influences tissue-level load capacity and mechanical adaptation.

Key Variables
Collagen synthesis markers · Protein availability & MPS · HRV recovery indices · Inflammatory cytokines (IL-6, CRP) · Tendon stiffness · Glycogen availability & force output
Study Design Direction
Repeated-measures crossover · Biomarker monitoring · Dietary intake analysis (FFQ, 24h recall) · Load-response curves under nutritional conditions
Developing Collagen Protein Synthesis Inflammation HRV Recovery
§ 02

Study Registry & Registered Investigations

#registry

All interventional research is pre-registered on ClinicalTrials.gov prior to data collection. Study IDs are permanent internal identifiers cross-referenced against NCT numbers, Zenodo/OSF archives, and DOI-registered publications. The table below shows the 5 foundational clinical studies; 17 studies are registered in total across all 8 research streams — including framework validation studies, reliability studies, observational registries, and normative data collection programs. Combined participant pool across registered clinical studies: n = 28,955+ across all studies.

MMSx Authority — Complete Study Registry 5 foundational clinical studies shown · 17 total registered · 3 NCT registrations · n = 28,955+ combined
Study ID Study Title & Design n Status NCT / Registry DOI / Archive Sites
MMSx-STU-001
MOVE Protocol — Movement-Oriented Velocity of Engagement
Multi-site interventional case-series · 8-week · 4-phase rehabilitation framework · GCP ICH E6(R3)
40 Final Peer-Reviewed Published NCT07220200
JMMBS
GFFI New Delhi (n=16)
BodyGNTX USA
IIKBS
MMSx-STU-002
BPIT 5-Line Pilot — Strength, HRV & Injury Risk Reduction
Prospective single-site interventional · Paired t-tests α=0.05 · Cohen's d effect size · Pre-registered SAP
23 Final Peer-Reviewed Published NCT07296640 10.5281/zenodo.17594977
BodyGNTX USA
MMSx-STU-003
BPIT Multi-Cohort International Validation
Multi-site observational · Mixed-effects ANOVA · Cross-site reproducibility · 5 partner institutions
369 Aggregated 392 Preprint Under Review NCT07256717 10.5281/zenodo.17551763
BodyGNTX · GFFI
IIKBS · AIHFT
Bureau of Fitness
MMSx-STU-004
MMSx-SCAN™ Inter-Rater Reliability & Normative Reference Values
ICC(2,1) reliability study · n=120 subsample · 5 raters · Shrout & Fleiss (1979) · SEM & MDC95
870 Registry pool Peer-Reviewed Published
10.66078/JMMBS.2026.V3I1.016
Multi-site · 5 raters
Independent assessors
MMSx-STU-005
MMSx-SCAN™ Multi-Site Movement Intelligence Registry
Observational registry · Cross-sectional · Optional 4-week and 12-week follow-up · Sites recruiting globally
Open Enrolling Active — Enrolling
NCT pending
International · Sites recruiting
§ 03

Publications & DOI-Registered Outputs

#pubs
JMMBS · Peer-Reviewed 2026 · Vol. 3 Issue 1
MMSx-SCAN™ Multi-Site Movement Assessment: Inter-Rater Reliability and Population-Stratified Normative Reference Values
Mehta, N. et al.
Journal of Movement Mechanics & Biomechanics Science
DOI: 10.66078/JMMBS.2026.V3I1.016
JMMBS · Peer-Reviewed 2026
MOVE Protocol — Movement-Oriented Velocity of Engagement: A Multi-Site Interventional Case-Series in Applied Rehabilitation Biomechanics
Mehta, N. et al. · ClinicalTrials.gov: NCT07220200
Journal of Movement Mechanics & Biomechanics Science
Published in JMMBS · ROAD Indexed
Preprint · Under Review 2025–2026
BPIT Multi-Cohort International Validation: Strength, HRV, and Injury-Mitigation Reproducibility Across Five International Sites
Mehta, N. et al. · ClinicalTrials.gov: NCT07256717 · n=369 (aggregated 392)
Zenodo Preprint Archive
DOI: 10.5281/zenodo.17551763
Open Dataset · OSF 2025 · Registered Nov 23
MMSx-SCAN™ Complete Study Dataset (n=870): Population-Stratified Normative Biomechanics Movement Scores
Mehta, N. et al. · Wikidata: Q136868966
Open Science Framework (OSF)
DOI: 10.17605/OSF.IO/F87N2 · CC BY 4.0
Framework Archive · Zenodo 2025
NEEBAL™ Principle Framework: Neural-Energy-Efficiency-Biomechanics-Alignment-Load — Theoretical and Applied Documentation
Mehta, N. · Wikidata: Q136871796
Zenodo
DOI: 10.5281/zenodo.17664904 · CC BY 4.0
§ 04

Open Datasets & Registered Archives

#data

All primary datasets are archived under CC BY 4.0 with permanent DOIs. Anonymised participant data, codebooks, and analysis scripts are available for independent verification. Wikidata IDs enable machine-readable disambiguation across scholarly databases. The open dataset pool spans 2,960+ participants across all registered studies. In addition, MMSx Authority has produced 100+ monographs and position papers and 40+ exercise blueprints archived through IMSO, Zenodo, and the JMMBS publishing infrastructure.

OSF
870
participants
MMSx-SCAN™ Complete Study Dataset
10 CSV files · 3.8 MB · Population-stratified normative scores
10.17605/OSF.IO/F87N2 Wikidata: Q136868966 · Registered Nov 23, 2025
CC BY 4.0
Zenodo
CERN
369
participants
BPIT Multi-Cohort Validation Dataset
Multi-site · 5 institutions · NCT07256717 · Aggregated n=392
10.5281/zenodo.17551763 Wikidata: Q136869057
CC BY 4.0
Zenodo
CERN
framework
NEEBAL™ Principle Framework Archive
Neural-Energy-Efficiency-Biomechanics-Alignment-Load · Theoretical documentation + applied protocols
10.5281/zenodo.17664904 Wikidata: Q136871796
CC BY 4.0
§ 05

Validated Research Frameworks

#frameworks

70+ proprietary biomechanical frameworks developed and validated within the MMSx Authority research program — spanning core movement mechanics, load modelling, clinical assessment, AI integration, and nutritional biomechanics. Each framework carries a Wikidata ID where registered, is archived with a DOI where applicable, and is used as the operational model for registered clinical investigations, published frameworks, monographs, or exercise blueprints. Selected major frameworks are detailed below.

Core Framework
MMSx Framework (Movement Mechanics Science)
Force-vector and torque-management treatment of human movement. Operationalises biomechanics as a mechanical decision science rather than descriptive anatomical vocabulary. Underpins all MMSx Authority research streams.
Core variables: Vector angle · Moment arm · Torque demand · Extensor capacity · Load tolerance threshold · Mechanical efficiency ratio
Validated Parent framework
Training Protocol
BPIT (5-Line Principle)
Biomechanics-Progressive Intervention Training. A structured 5-line training framework validated across pilot (n=23) and multi-cohort (n=369) studies with 15–25% strength gains, HRV improvement, and reduced knee valgus.
Outcomes: Strength +15–25% · HRV ↑ · Knee valgus ↓ · Wikidata: Q136869057 · NCT07296640 · NCT07256717
Peer-Reviewed Multi-cohort
Clinical Protocol
MOVE Protocol (4-Phase Rehab)
Movement-Oriented Velocity of Engagement. 8-week, 4-phase rehabilitation protocol. Multi-site interventional case-series demonstrating significant improvements in pain, functional capacity, balance, and sit-to-stand performance.
Outcomes: Pain ↓ · Functional capacity ↑ · Balance ↑ · STS ↑ · Wikidata: Q136874190 · NCT07220200
Peer-Reviewed n=40
Load Modelling
MOLOCH (Overload Hierarchy)
Mechanical Overload & Load-Capacity Hierarchy. Theoretical model for cumulative mechanical stress, tissue tolerance threshold determination, and progressive load sequencing across rehabilitation and training contexts.
Variables: Cumulative load index · Tissue tolerance threshold · Recovery ratio · Load-capacity gap · Progressive exposure rate
Developing Theoretical
Assessment System
MMSx-SCAN™ (Movement Assessment)
Structured clinical movement assessment system. ICC(2,1) inter-rater reliability of 0.91 across 5 raters. Population-stratified normative reference values published in JMMBS. Primary instrument for RS-005.
Psychometrics: ICC(2,1) = 0.91 · SEM computed · MDC95 established · n=870 normative sample · Wikidata: Q136868966
Peer-Reviewed JMMBS 2026
Neuro-Mechanical
NEEBAL™ (6-Axis Principle)
Neural-Energy-Efficiency-Biomechanics-Alignment-Load. Six-axis framework integrating neurological, energetic, and biomechanical load factors into a unified movement efficiency model. Archived on Zenodo.
Axes: Neural · Energy · Efficiency · Biomechanics · Alignment · Load · Wikidata: Q136871796 · DOI: 10.5281/zenodo.17664904
Preprint Zenodo
AI Framework
TrainersEye AI (Motion Intelligence)
AI-powered movement analysis framework integrating pose estimation, pattern recognition, and real-time kinematic scoring for clinical and field-based assessment. Powers the Motion Map, MoPro Bot, and MMO Assessment platforms within RS-007.
Technologies: Markerless pose estimation · Computer vision · LSTM classifiers · Joint angle automation · Real-time feedback · Clinical decision support layer
Active RS-007
Nutrition–Mechanics
NutriBiomech™ (Load-Nutrition Interface)
Theoretical and applied framework linking nutritional biochemistry to musculoskeletal load capacity. Maps macro- and micronutrient status to connective tissue integrity, HRV-based recovery, and neuromuscular force output under progressive mechanical load. RS-008 primary framework.
Domains: Collagen synthesis · MPS · Anti-inflammatory nutrition · Glycogen-force coupling · Tendon mechanobiology · Recovery HRV markers
Developing RS-008
§ 06

Research Governance & Ethics Compliance

#governance
Standard / Framework Domain Applies To Verified
GCP ICH E6(R3) Good Clinical Practice — trial conduct, documentation, investigator responsibilities NCT07220200 · NCT07296640 · NCT07256717
Declaration of Helsinki Ethical principles for medical research involving human subjects (2013 revision) All clinical investigations
CONSORT 2010 Consolidated Standards of Reporting Trials — interventional study reporting MMSx-STU-001 · STU-002
STROBE Strengthening the Reporting of Observational Studies in Epidemiology MMSx-STU-003 · STU-004 · STU-005
PRISMA 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Systematic reviews
Pre-Registered SAP Statistical Analysis Plan locked before data collection — independent statistician verification All interventional studies
Open Data Policy CC BY 4.0 datasets archived on OSF and Zenodo — independently downloadable and verifiable MMSx-STU-003 · STU-004
COI Disclosure Conflict of interest disclosed on all publications; multi-site data by independently employed assessors All outputs
IMSO S101 Movement intelligence assessment standard — MMSx Authority proprietary governance framework MMSx-SCAN™ assessment
§ 07

Persistent Identifiers & Global Registry

#ids

Every researcher, institution, framework, and dataset within MMSx Authority carries a permanent machine-readable identifier enabling unambiguous citation, cross-database disambiguation, and automated discovery by scholarly indexing systems.

Institute ISNI
0000 0005 3015 0322
Ringgold ID
848200
Wikidata — Institute
JMMBS DOI Prefix
10.66078
JMMBS ISSN (Online)
3070-3662
Institute EIN
41-2717794 · 501(c)(3)
GitHub Organisation
ClinicalTrials — MOVE
ClinicalTrials — BPIT Pilot
ClinicalTrials — BPIT Multi
Wikidata — MMSx-SCAN™
Wikidata — BPIT™
Wikidata — NEEBAL™
Wikidata — MOVE™
Open Dataset DOI
§ 08

Affiliated Institutions & Research Partners

#aff
Institution Lead Investigator Affiliation Type Reference ID Year
🇪🇸 Instituto de Biomecánica Clínica (IBC), Spain
Prof. Dr. José Luis Parreño Catalán
Director, Dept of Biomechanics · PhD Cum Laude, USC
Research Affiliate MMSx-AFF-IBC-2026-01 Jan 2026
🇮🇳 GFFI Fitness Academy, New Delhi, India
Research Site Coordinator
MOVE Protocol clinical site · n=16 participants
Clinical Site Site: NCT07220200-IND-01 2025–26
🇺🇸 BodyGNTX Institute, USA
Clinical Research Site
MOVE Protocol + BPIT multi-cohort site
Clinical Site NCT07220200 · NCT07256717 2024–26
Interested in institutional affiliation or clinical site participation? Contact the Research Office →
Disclaimer: Content in this research portal is provided for scientific and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Clinical decisions must remain the responsibility of licensed healthcare professionals. Non-peer-reviewed outputs are clearly labelled and should not be interpreted as established clinical evidence. Preprints have not yet been formally peer-reviewed and should be interpreted accordingly.